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ipsc line  (iXCells Biotechnologies)


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    iXCells Biotechnologies ipsc line
    Ipsc Line, supplied by iXCells Biotechnologies, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/human+ipsc+lines/Human+Motor+Neurons/bio_rxiv__64898__2026__02__23__707492-182-5-23
    Average 94 stars, based on 1 article reviews
    ipsc line - by Bioz Stars, 2026-09
    94/100 stars

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    Related Articles

    Imaging:

    Article Title: Inhibition of de novo ceramide synthesis mitigates alpha-synuclein pathology in a Parkinson's disease mouse model.
    Article Snippet: .. Midbrain organoid differentiation and imaging Midbrain organoids were generated from human iPSC lines obtained from a healthy donor (iXCells, Cat# 30HU-002) or a Parkinson's disease patient (iXCells, Cat# 30HU-003). ..

    Generated:

    Article Title: Inhibition of de novo ceramide synthesis mitigates alpha-synuclein pathology in a Parkinson's disease mouse model.
    Article Snippet: .. Midbrain organoid differentiation and imaging Midbrain organoids were generated from human iPSC lines obtained from a healthy donor (iXCells, Cat# 30HU-002) or a Parkinson's disease patient (iXCells, Cat# 30HU-003). ..

    Article Title: Inhibition of de novo ceramide synthesis mitigates alpha-synuclein pathology in a Parkinson’s disease mouse model
    Article Snippet: .. Midbrain organoids were generated from human iPSC lines obtained from a healthy donor (iXCells, Cat# 30HU-002) or a Parkinson’s disease patient (iXCells, Cat# 30HU-003). ..



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    Image Search Results


    ( A ) Schematic overview of the in vitro experimental design to test the Alu insertion’s functional impact in the human induced pluripotent stem cell (iPSC) line, KOLF2.1J. ( B ) Expression of OCA2 and melanocyte marker genes across seven stages of melanocyte differentiation (days 0, 2, 8, 16, 19, 25, and 30). Each dot represents a technical replicate (heterozygous insertion carriers, red; wildtype, gray). Lines indicate the mean across two replicates at each time point. Two OCA2 amplicons are shown: exon 11-13 and exon 16-18 (exon numbering from RefSeq NM_000275.3 as displayed in the UCSC Genome Browser). ( C ) Representative image illustrating pigmentation differences between wild-type (WT; homozygous reference) and heterozygous (HET; one Alu insertion allele) melanocyte cultures. ( D ) Enrichment of histone marks, H3K4me1 and H3K27ac, at days 19 and 30. “IgG” and “Control” indicate negative controls for the enrichment assay and locus-specific signal, respectively. The locus “Control” is derived from the B2M gene. Fold enrichment values were normalized to 1% of the input control. [Figure created with BioRender]

    Journal: bioRxiv

    Article Title: A Denisovan-derived Alu insertion in OCA2 contributes to pigmentation diversity in present-day Melanesians

    doi: 10.64898/2026.03.18.712481

    Figure Lengend Snippet: ( A ) Schematic overview of the in vitro experimental design to test the Alu insertion’s functional impact in the human induced pluripotent stem cell (iPSC) line, KOLF2.1J. ( B ) Expression of OCA2 and melanocyte marker genes across seven stages of melanocyte differentiation (days 0, 2, 8, 16, 19, 25, and 30). Each dot represents a technical replicate (heterozygous insertion carriers, red; wildtype, gray). Lines indicate the mean across two replicates at each time point. Two OCA2 amplicons are shown: exon 11-13 and exon 16-18 (exon numbering from RefSeq NM_000275.3 as displayed in the UCSC Genome Browser). ( C ) Representative image illustrating pigmentation differences between wild-type (WT; homozygous reference) and heterozygous (HET; one Alu insertion allele) melanocyte cultures. ( D ) Enrichment of histone marks, H3K4me1 and H3K27ac, at days 19 and 30. “IgG” and “Control” indicate negative controls for the enrichment assay and locus-specific signal, respectively. The locus “Control” is derived from the B2M gene. Fold enrichment values were normalized to 1% of the input control. [Figure created with BioRender]

    Article Snippet: We used the human iPSC line KOLF2.1J (The Jackson Laboratory) for all differentiation experiments.

    Techniques: In Vitro, Functional Assay, Expressing, Marker, Control, Derivative Assay